Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pax6  paired box 6   (Synonyms: 1500038E17Rik, AEY11, Dey, Dickie's small eye, Gsfaey11, Pax-6)
Results	Reference
1	J:38786 Anchan RM, Drake DP, Haines CF, Gerwe EA, LaMantia AS, Disruption of local retinoid-mediated gene expression accompanies abnormal development in the mammalian olfactory pathway [published erratum appears in J Comp Neurol 1997 Jul 28;384(2):321]. J Comp Neurol. 1997 Mar 10;379(2):171-84
1	J:127387 Armentano M, Chou SJ, Tomassy GS, Leingartner A, O'Leary DD, Studer M, COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas. Nat Neurosci. 2007 Oct;10(10):1277-86
1*	J:71879 Bernier G, Vukovich W, Neidhardt L, Herrmann BG, Gruss P, Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium. Development. 2001 Oct;128(20):3987-94
1	J:171429 Besse L, Neti M, Anselme I, Gerhardt C, Ruther U, Laclef C, Schneider-Maunoury S, Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing. Development. 2011 May;138(10):2079-88
1*	J:136314 Burns CJ, Zhang J, Brown EC, Van Bibber AM, Van Es J, Clevers H, Ishikawa TO, Taketo MM, Vetter ML, Fuhrmann S, Investigation of Frizzled-5 during embryonic neural development in mouse. Dev Dyn. 2008 Jun;237(6):1614-26
1	J:198381 Carbe C, Garg A, Cai Z, Li H, Powers A, Zhang X, An allelic series at the paired box gene 6 (Pax6) locus reveals the functional specificity of Pax genes. J Biol Chem. 2013 Apr 26;288(17):12130-41
1	J:245758 Carreno G, Apps JR, Lodge EJ, Panousopoulos L, Haston S, Gonzalez-Meljem JM, Hahn H, Andoniadou CL, Martinez-Barbera JP, Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors. Development. 2017 Sep 15;144(18):3289-3302
1*	J:80954 Chapman DL, Papaioannou VE, Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature. 1998 Feb 12;391(6668):695-7
1*	J:89228 Chen MH, Li YJ, Kawakami T, Xu SM, Chuang PT, Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 2004 Mar 15;18(6):641-59
1*	J:18916 Dickinson ME, Krumlauf R, McMahon AP, Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system. Development. 1994 Jun;120(6):1453-71
1*	J:49164 Ding Q, Motoyama J, Gasca S, Mo R, Sasaki H, Rossant J, Hui CC, Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development. 1998 Jul;125(14):2533-43
1*	J:206224 Dixit R, Tachibana N, Touahri Y, Zinyk D, Logan C, Schuurmans C, Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation. Gene Expr Patterns. 2014 Jan;14(1):42-54
1	J:194843 Ferri A, Favaro R, Beccari L, Bertolini J, Mercurio S, Nieto-Lopez F, Verzeroli C, La Regina F, De Pietri Tonelli D, Ottolenghi S, Bovolenta P, Nicolis SK, Sox2 is required for embryonic development of the ventral telencephalon through the activation of the ventral determinants Nkx2.1 and Shh. Development. 2013 Mar;140(6):1250-61
1	J:134674 Fogel JL, Chiang C, Huang X, Agarwala S, Ventral specification and perturbed boundary formation in the mouse midbrain in the absence of Hedgehog signaling. Dev Dyn. 2008 May;237(5):1359-72
1	J:343606 Francis RJB, San Agustin JT, Szabo Rogers HL, Cui C, Jonassen JA, Eguether T, Follit JA, Lo CW, Pazour GJ, Autonomous and non-cell autonomous role of cilia in structural birth defects in mice. PLoS Biol. 2023 Dec;21(12):e3002425
1	J:147382 Genethliou N, Panayiotou E, Panayi H, Orford M, Mean R, Lapathitis G, Malas S, Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord. Biochem Biophys Res Commun. 2009 Apr 24;382(1):69-73
1	J:108511 Griesel G, Treichel D, Collombat P, Krull J, Zembrzycki A, van den Akker WM, Gruss P, Simeone A, Mansouri A, Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border. Development. 2006 May;133(9):1779-87
1*	J:25250 Grindley JC, Davidson DR, Hill RE, The role of Pax-6 in eye and nasal development. Development. 1995 May;121(5):1433-42
1*	J:41401 Grindley JC, Hargett LK, Hill RE, Ross A, Hogan BL, Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon. Mech Dev. 1997 Jun;64(1-2):111-26
1	J:110708 Guimera J, Vogt Weisenhorn D, Echevarria D, Martinez S, Wurst W, Molecular characterization, structure and developmental expression of Megane bHLH factor. Gene. 2006 Aug 1;377:65-76
1	J:96705 Hamasaki T, Leingartner A, Ringstedt T, O'Leary DD, EMX2 regulates sizes and positioning of the primary sensory and motor areas in neocortex by direct specification of cortical progenitors. Neuron. 2004 Aug 5;43(3):359-72
1*	J:66532 Hecksher-Sorensen J, Sharpe J, 3D confocal reconstruction of gene expression in mouse. Mech Dev. 2001 Jan;100(1):59-63
1	J:142506 Hoover AN, Wynkoop A, Zeng H, Jia J, Niswander LA, Liu A, C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development. 2008 Dec;135(24):4049-58
1	J:103123 Kawauchi S, Shou J, Santos R, Hebert JM, McConnell SK, Mason I, Calof AL, Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development. 2005 Dec;132(23):5211-23
1	J:58952 Kioussi C, O'Connell S, St-Onge L, Treier M, Gleiberman AS, Gruss P, Rosenfeld MG, Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14378-82
1*	J:107595 Landsberg RL, Awatramani RB, Hunter NL, Farago AF, DiPietrantonio HJ, Rodriguez CI, Dymecki SM, Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6. Neuron. 2005 Dec 22;48(6):933-47
1	J:183997 Langer L, Taranova O, Sulik K, Pevny L, SOX2 hypomorphism disrupts development of the prechordal floor and optic cup. Mech Dev. 2012 Mar;129(1-4):1-12
1	J:100591 Lee HY, Wroblewski E, Philips GT, Stair CN, Conley K, Reedy M, Mastick GS, Brown NL, Multiple requirements for Hes 1 during early eye formation. Dev Biol. 2005 Aug 15;284(2):464-78
1	J:193919 Lu F, Kar D, Gruenig N, Zhang ZW, Cousins N, Rodgers HM, Swindell EC, Jamrich M, Schuurmans C, Mathers PH, Kurrasch DM, Rax is a selector gene for mediobasal hypothalamic cell types. J Neurosci. 2013 Jan 2;33(1):259-72
1*	J:47724 McMahon JA, Takada S, Zimmerman LB, Fan CM, Harland RM, McMahon AP, Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 1998 May 15;12(10):1438-52
1	J:119026 Morcillo J, Martinez-Morales JR, Trousse F, Fermin Y, Sowden JC, Bovolenta P, Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH. Development. 2006 Aug;133(16):3179-90
1	J:60644 Nagai T, Aruga J, Minowa O, Sugimoto T, Ohno Y, Noda T, Mikoshiba K, Zic2 regulates the kinetics of neurulation. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1618-23
1	J:38554 Nagai T, Aruga J, Takada S, Gunther T, Sporle R, Schughart K , Mikoshiba K, The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation. Dev Biol. 1997 Feb 15;182(2):299-313
1*	J:68840 Nakagawa Y, O'Leary DD, Combinatorial expression patterns of LIM-homeodomain and other regulatory genes parcellate developing thalamus. J Neurosci. 2001 Apr 15;21(8):2711-25
1	J:285050 Ochi S, Imaizumi Y, Shimojo H, Miyachi H, Kageyama R, Oscillatory expression of Hes1 regulates cell proliferation and neuronal differentiation in the embryonic brain. Development. 2020 Feb 26;147(4):dev182204
1*	J:309436 Parish EV, Mason JO, Price DJ, Expression of Barhl2 and its relationship with Pax6 expression in the forebrain of the mouse embryo. BMC Neurosci. 2016 Nov 25;17(1):76
1*	J:26182 Schubert FR, Fainsod A, Gruenbaum Y, Gruss P, Expression of the novel murine homeobox gene Sax-1 in the developing nervous system. Mech Dev. 1995 May;51(1):99-114
1	J:71636 Sun T, Echelard Y, Lu R, Yuk D, Kaing S, Stiles CD, Rowitch DH, Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr Biol. 2001 Sep 18;11(18):1413-20
1	J:55842 Sussel L, Marin O, Kimura S, Rubenstein JL, Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development. 1999 Aug;126(15):3359-70
1	J:157924 Tang K, Xie X, Park JI, Jamrich M, Tsai S, Tsai MJ, COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis. Development. 2010 Mar;137(5):725-34
1	J:198684 Trowe MO, Zhao L, Weiss AC, Christoffels V, Epstein DJ, Kispert A, Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Development. 2013 Jun;140(11):2299-309
1*	J:65597 van Raamsdonk CD, Tilghman SM, Dosage requirement and allelic expression of PAX6 during lens placode formation. Development. 2000 Dec;127(24):5439-48
1*	J:1914 Walther C, Gruss P, Pax-6, a murine paired box gene, is expressed in the developing CNS. Development. 1991 Dec;113(4):1435-49
1	J:194842 Yang J, Brown A, Ellisor D, Paul E, Hagan N, Zervas M, Dynamic temporal requirement of Wnt1 in midbrain dopamine neuron development. Development. 2013 Mar;140(6):1342-52
1	J:66590 Yun K, Potter S, Rubenstein JL, Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon. Development. 2001 Jan;128(2):193-205
1	J:119671 Zhang X, Rowan S, Yue Y, Heaney S, Pan Y, Brendolan A, Selleri L, Maas RL, Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development. Dev Biol. 2006 Dec 15;300(2):748-57
1	J:62712 Zhong W, Jiang MM, Schonemann MD, Meneses JJ, Pedersen RA, Jan LY, Jan YN, Mouse numb is an essential gene involved in cortical neurogenesis. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6844-9